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KMID : 0383119910390010069
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Journal of Aerospace Medicine
1991 Volume.39 No. 1 p.69 ~ p.96
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Effect of Hypoxia on the Reperfusion-Induced Arrhythmias in the Cat
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Yoon Young-Wook
Min Tae-Hyung
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Abstract
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This study was performed to investigate the effect of hypoxia on the reperfusion-induced arrhythmias in the 1:9 pentobarbital-anesthetized
cats. Reperfusion-induced arrhythmias were elicited by occlusion of the left anterior descending coronary artery for 10 minutes and subsequent release. 1 minute before reperfusion, cats were ventilated with normal room air or 5 % oxygen.
The results were summarized as follows:
1) In the cats which were ventilated with normal room air during reperfusion, premature ventricular beats and ventricular tachycardia in reperfusion were rapid in onset than those occurred in antecedant 10 minutes ischemia (p <0.01 ) , and the incidence of ventricular tachycardia and ventricular fibrillation was 40% and 30% respectively.
2) In the cats which were ventilated with 5% oxygen during reperfusion, premature ventricular beats and ventricular tachy cardia in reperfusion were rapid onset than those occurred in antecedant 10 minutes ischemia (p <0.01 ) . The incidence of ventricular tachycardia and ventricular fibrillation during reperfusion was 89% and 78% respectively, which was significantly higher than that obtained in antecedent 10 minutes ischemia (p < 0.1 ) .
3) The incidence of reperfusion induced ventricular tachycardia and ventricuar fibrillation was increased in the cats ventilated with 5% oxygen for 5 minutes during reperfusion than that in the cats ventilated with room air.
4) To summarize above results, it suggests that the arrhythmias might be rapid in onset and more severe in reperfusion than in ischemia and readmission of oxygen might be not generate the reperfusion-induced arrhythmias.
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